OralCard: A bioinformatic tool for the study of oral proteome



The molecular complexity of the human oral cavity can only be clarified through identification of components that participate within it. However current proteomic techniques produce high volumes of information that are dispersed over several online databases. Collecting all of this data and using an integrative approach capable of identifying unknown associations is still an unsolved problem. This is the main motivation for this work.

We present the online bioinformatic tool OralCard, which comprises results from 55 manually curated articles reflecting the oral molecular ecosystem (OralPhysiOme). It comprises experimental information available from the oral proteome both of human (OralOme) and microbial origin (MicroOralOme) structured in protein, disease and organism.

This tool is a key resource for researchers to understand the molecular foundations implicated in biology and disease mechanisms of the oral cavity. The usefulness of this tool is illustrated with the analysis of the oral proteome associated with diabetes melitus type 2. OralCard is available at




Archives of Oral Biology, Vol. 58, #7, pp. 762-772, February 2013


Cited by

Year 2016 : 4 citations

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Year 2015 : 7 citations

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Year 2014 : 11 citations

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 Bragazzi, Nicola Luigi, Eugenia Pechkova, and Claudio Nicolini. "Proteomics and proteogenomics approaches for oral diseases." Adv Protein Chem Struct Biol 95 (2014): 125-162.

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 Lopes, Ricardo Jorge Nogueira. Interactoma da cavidade oral em diabetes. Diss. 2014.

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 Moreira, Patrícia Maria Iria. Os microorganismos orais e o oraloma da diabetes tipo 2. Diss. 2013.

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Year 2013 : 4 citations

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