The Responsible AI Laboratory (RAIL) is a transversal research initiative at CISUC, University of Coimbra, dedicated to the development of transparent, fair, trustworthy, and sustainable AI systems. Bringing together researchers from multiple CISUC groups, RAIL provides a coordinated framework to advance research on explainable and human-centered AI, fairness and bias mitigation, reliability and robustness, ethical and legal compliance, and the societal impact of AI technologies. Building on CISUC’s strong track record in responsible AI and its engagement in national and international networks, RAIL aims to foster collaboration, support innovation, and position CISUC as a long-term reference in responsible AI research and practice.